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Nifedipine appears to enhance the absorption of Metformin.
Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin) could potentially interact with metformin by competing for common renal tubular transport systems.
Cimetidine increases peak plasma concentration of metformin and whole blood concentrations.
Certain drugs such as thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid, tend to produce hyperglycemia and may lead to loss of glycemic control. Monitor closely for loss of blood glucose control in patients taking these drugs. When such drugs are withdrawn from a patient receiving metformin, the patient should be closely observed for hypoglycemia.
